Reference Regimen
This is the baseline schedule every comparator is measured against.
Edit reference regimen Apply a generated preset or fine-tune the current schedule
Fine-tune reference
Field edits apply automatically.
Current setup
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Patient Profile
Start with one of the two common model profiles. Choose custom only when you need to enter a different dose or patient assumption.
Custom profile selected
Set the reference dose
Enter a weight-based weekly protocol dose or the total product amount. Every reference and comparator preset updates from this dose.
Advanced settings Product, cartridges, infusion setup, and simulation assumptions
Product and infusion setup
Product selection changes feasible volume, cartridge counts, and estimated infusion time.
Cartridge selection
Simulation assumptions
The simulation starts from zero exposure at day 0 and normalizes to the reference regimen's final 28-day average.
Advanced IgG assumptions Baseline, dose slope, thresholds, and uncertainty
Comparator Regimens
Comparators are alternatives to the reference. Choose one to edit, optionally apply a generated preset, then fine-tune it.
1
Choose which comparator to editThe highlighted comparator is used by the editor below.
2
Choose a starting scheduleA preset replaces the selected comparator only after you click Apply.
3
Fine-tune Edit the name, cycle, dose days, volumes, or sites.
Results
Comparator Graphs
Choose a view of the reference and comparator schedules.
Estimated IgG Bands
Compare modeled steady-state and post-switch IgG bands across schedules.
center line = modeled midpoint
shaded band = editable uncertainty range
dotted lines = lab reference range for orientation
vertical markers = dose events
Edit uncertainty assumptions Default: absorption 1-3 days, elimination 21-35 days
Estimated IgG bands by schedule
Final 42 days of each schedule, scaled from the selected scenario and uncertainty settings.
Estimated IgG band after switch
Reference schedule before day 0, then each comparator begins at the switch.
View estimated IgG tables Steady swing estimates, scenario anchor, and delayed-dose waning
Dose-gap modeling
Extended Interval Explorer
Start from a stable regimen, withhold every dose after day 0, and follow the modeled IgG band toward its non-zero endogenous baseline.
What this answers
How far might the level drift by day 7, 14, 21, or 28?
Threshold crossings
First downward crossing after the post-dose peak. A range reflects the editable PK and calibration uncertainty.
Common interval checkpoints
Modeled IgG range if the next dose has still not been taken on that day.
The curve approaches the editable pre-SCIG baseline rather than zero. Pair this model with observed symptoms and measured labs; it is not a dose-change recommendation.